Comparative Adverse Effect of some Common Household Chemicals on Both liver and kidney of Albino rat
Keywords:
Bisphenol A (BPA) - 2-Beutoxyethanol (2-BE) - Kidney- liver- Albino ratAbstract
Kidney and liver are target organs playing a major role in excretion and elimination of the body waste metabolites and they are sensitive to action of the toxic agents. Thus the present study was designed to compare and assess hepatic and renal tissues injuries induced by common household chemicals namely Bisphenol A (BPA) and 2-Beutoxyethanol (2-BE) in adult male albino rat (Rattus norvegicus). Oral treatment with sub-lethal dose (200 mg/kg/day) for 15days resulted in different histopathological effects in both liver and kidney of male albino rat(Rattus norvegicus). Fatty change liver, necrotic hepatocytes, congested blood, infiltration of polymorph leukocytes, pyknotic hepatocytes and aggregation of melanomacrophages in the hepatic tissue were observed. While in kidney; shrinkage and atrophy of glomeruli, hypertrophy of glomeruli with glomerular distortion, necrotic renal tubules, stagnation fluid in renal tubules, severe atrophy of renal tubules and some macrophages cells were observed.
References
Oehlmann, J., Schulte-Oehlmann, U., Kloas, W., Jagnytsch, O., Lutz, I., Kusk, K. O., ... & Tyler, C. R.
(2009). A critical analysis of the biological impacts of plasticizers on wildlife. Philosophical
Transactions of the Royal Society B: Biological Sciences, 364(1526), 2047-2062.
doi.org/10.1098/rstb.2008.0242.
Gao, X., Kang, S., Xiong, R., & Chen, M. (2020). Environment-friendly removal methods for endocrine
disrupting chemicals. Sustainability, 12(18), 7615. doi:10.3390/su12187615.
Ahmed, W. M., Moselhy, W. A., & Nabil, T. M. (2015). Bisphenol A toxicity in adult male rats:
hematological, biochemical and histopathological approach. Global veterinaria, 14(2),
-238.Angerer, J.; Ewers, U. and Wilhelm, M. Human biomonitoring: state of the art. International
Journal of Hygiene and Environmental Health, 2007, 210, 201-228. doi:
5829/idosi.gv.2015.14.02.9332.
de Boer, J., Fritsche, E., Schoeters, G., & Kimber, I. (2015). The European Long-range Research
Initiative (LRI): A decade of contributions to human health protection, exposure modelling and
environmental integrity. Toxicology, 337, 83-90. doi: 10.1016/j.tox.2015.09.003.
Carson, P. A. (2002). Hazardous chemicals handbook. Elsevier. Hardcover ISBN:
Peretz, J., Vrooman, L., Ricke, W. A., Hunt, P. A., Ehrlich, S., Hauser, R., ... & Flaws, J. A. (2014).
Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013.
Environmental health perspectives, 122(8), 775-786. doi: 10.1289/ehp.1307728
Cogliano, V. J., Grosse, Y., Baan, R. A., Straif, K., Secretan, M. B., Ghissassi, F. E., & Working Group for
Volume 88. (2005). Meeting report: summary of IARC monographs on formaldehyde,
-butoxyethanol, and 1-tert-butoxy-2-propanol. Environmental health perspectives, 113(9), 1205-1208.
doi: 10.1289/ehp.7542
Le, H. H., Carlson, E. M., Chua, J. P., & Belcher, S. M. (2008). Bisphenol A is released from
polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar
neurons. Toxicology letters, 176(2), 149-156. doi: 10.1016/j.toxlet.2007.11.001
Elshaer, F.M., Khalaf-Allahf, H.M.M., Bkry, S., Tawfiek, Z. and Abu-Shaeir, W.A. Comparative Studies
on the Anatomical Changes Induced by Bisphenol A (BPA) on Some Vertebrate Species. Ph.D. Thesis,
Zool.Dep. Fac.Sci., Al-Azhar Univ., Egypt., 2014, 212 pp.
Richter, C. A., Birnbaum, L. S., Farabollini, F., Newbold, R. R., Rubin, B. S., Talsness, C. E., ... & vom
Saal, F. S. (2007). In vivo effects of bisphenol A in laboratory rodent studies. Reproductive toxicology,
(2), 199-224. doi: 10.1016/j.reprotox.2007.06.004
Kang, J. H., Katayama, Y., & Kondo, F. (2006). Biodegradation or metabolism of bisphenol A: from
microorganisms to mammals. Toxicology, 217(2-3), 81-90. doi: 10.1016/j.tox.2005.10.001.
Traynor, M. J., Wilkinson, S. C., & Williams, F. M. (2008). Metabolism of butoxyethanol in excised
human skin in vitro. Toxicology letters, 177(3), 151-155. doi: 10.1016/j.toxlet.2008.01.013.
Hung, P. C., Cheng, S. F., Liou, S. H., & Tsai, S. W. (2011). Biological monitoring of low-level
-butoxyethanol exposure in decal transfer workers in bicycle manufacturing factories. Occupational
and environmental medicine, 68(10), 777-782. doi: 10.1016/j.toxlet.2008.01.013.
ETHER, M. (2010). TOXICOLOGICAL REVIEW OF ETHYLENE GLYCOL MONOBUTYL ETHER
(EGBE)(CAS No. 111-76-2).
Karnam, S. S., Ghosh, R. C., & Mondal, S. (2016). EFFECT OF BISPHENOL-A ON IMMUNE SYSTEM
OF WISTAR RATS. Exploratory Animal and Medical Research, 6(1), 47-52.
Baselt, R. Disposition of Toxic Drugs and Chemicals in Man (8th ed.). Foster City, CA: Biomedical
Publications. 2008, pp. 208–210. doi: 10.1097/MJT.0b013e31818de2e2
Omar, A. M. S. (2013). Histopathological and physiological effects of liver and kidney in rats exposed
to cadmium and ethanol. Global Advanced Research Journal of Environmental, 2(3), 93-106.
WASSN 2021 8 of 8
Ashwood, E. R., Aldrich, J. E., & Tietz, N. W. (1996). Tietz fundamentals of clinical chemistry.
Saunders.
Hassan, Z. K., Elobeid, M. A., Virk, P., Omer, S. A., ElAmin, M., Daghestani, M. H., & AlOlayan, E. M.
(2012). Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxidative medicine
and cellular longevity, 2012. doi.org/10.1155/2012/194829
Roy, S., Kalita, C. J., & Mazumdar, M. (2011). Histopathlogical effects of Bisphenol A on liver of
Heteropneustes Fossilis (Bloch). An international Quarterly Journal of Environmental Sciences the
Ecoscan, 1, 187-190.
Hussein, R. M., & Eid, J. I. (2013). Pathological mechanisms of liver injury caused by oral
administration of bisphenol A. Life Science Journal, 10(1), 663.
Daniela-Saveta, P. O. P. A., Bolfa, P., Bela, K. I. S. S., Vlase, L., Păltinean, R., Anca, P. O. P., ... & Loghin,
F. (2014). Influence of genista tinctoria l or methylparaben on subchronic toxicity of bisphenol a in rats.
Biomedical and environmental sciences, 27(2), 85-96. doi: 10.3967/bes2014.021.
Yamaguchi, P. Histopathological and electron microscopic changes in mice treated with puffer fish
toxin. Journal of Toxicological Science 1996, (1): 1-14. doi: 10.2131/jts.21.supplementi_1.
Metcalfe, C. D. (1998). Toxicopathic responses to organic compounds. Fish Diseases and Disorders:
Non-infectious Disorders, vol. 2.
Korkmaz, A., Ahbab, M. A., Kolankaya, D., & Barlas, N. (2010). Influence of vitamin C on bisphenol A,
nonylphenol and octylphenol induced oxidative damages in liver of male rats. Food and Chemical
Toxicology, 48(10), 2865-2871. doi: 10.1016/j.fct.2010.07.019.
Camargo, M. M., & Martinez, C. B. (2007). Histopathology of gills, kidney and liver of a Neotropical
fish caged in an urban stream. Neotropical Ichthyology, 5(3), 327-336.
Gengerich, W. H. (1982). Hepatic toxicology of fishes In: Aquatic toxicology. Raven, Prees NY, 55, 106.
Mollendroff, P.G. (1973): Cytology and cell physiology. 3rd ed. Academic Press. New York.
Benjamin, N., Kushwah, A., Sharma, R. K., & Katiyar, A. K. (2006). Histopathological changes in liver,
kidney and muscles of pesticides exposed malnourished and diabetic rats.
Long, E. R., MacDonald, D. D., Smith, S. L., & Calder, F. D. (1995). Incidence of adverse biological
effects within ranges of chemical concentrations in marine and estuarine sediments. Environmental
management, 19(1), 81-97.
Meinelt, T., Krüger, R., Pietrock, M., Osten, R., & Steinberg, C. (1997). Mercury pollution and
macrophage centres in pike (Esox lucius) tissues. Environmental science and Pollution research, 4(1),
-36. doi: 10.1007/BF02986262
Afshar, S., Farshid, A. A., Heidari, R., & Ilkhanipour, M. (2008). Histopathological changes in the liver
and kidney tissues of Wistar albino rat exposed to fenitrothion. Toxicology and industrial health, 24(9),
-586. doi.org/10.1177/0748233708100090
Akingbemi, B. T., Sottas, C. M., Koulova, A. I., Klinefelter, G. R., & Hardy, M. P. (2004). Inhibition of
testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary
luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig
cells. Endocrinology, 145(2), 592-603. doi: 10.1210/en.2003-1174.
Sangai, N. P., Verma, R. J., & Trivedi, M. H. (2014). Testing the efficacy of quercetin in mitigating
bisphenol A toxicity in liver and kidney of mice. Toxicology and industrial health, 30(7), 581-597.
doi.org/10.1177/0748233712457438
Takashima, F., & Hibiya, T. (1995). An atlas of fish histology: normal and pathological features.
Saenphet, S., Thaworn, W., & Saenphet, K. (2009). Histopathological alterations of the gills, liver and
kidneys in Anabas testudineus (Bloch) fish living in an unused lignite mine, li district, Lamphun
province, Thailand. Southeast Asian journal of tropical medicine and public health, 40(5), 1121.
Humanson, G. L. (1979). Animal tissue techniques (No. QM 556. H85 1979).
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 WAS Science Nature (WASSN) ISSN: 2766-7715
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
